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KMID : 0545120190290030339
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Journal of Microbiology and Biotechnology
2019 Volume.29 No. 3 p.339 ~ p.346
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Metabolic Engineering for Improved Fermentation of L-Arabinose
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Ye Su-Ji
Kim Jeong-Won
Kim Soo-Rin
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Abstract
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L-Arabinose, a five carbon sugar, has not been considered as an important bioresource because most studies have focused on D-xylose, another type of five-carbon sugar that is prevalent as a monomeric structure of hemicellulose. In fact, L-arabinose is also an important monomer of hemicellulose, but its content is much more significant in pectin (3-22%, g/g pectin), which is considered an alternative biomass due to its low lignin content and mass production as juiceprocessing waste. This review presents native and engineered microorganisms that can ferment L-arabinose. Saccharomyces cerevisiae is highlighted as the most preferred engineering host for expressing a heterologous arabinose pathway for producing ethanol. Because metabolic engineering efforts have been limited so far, with this review as momentum, more attention to research is needed on the fermentation of L-arabinose as well as the utilization of pectin-rich biomass.
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KEYWORD
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L-arabinose, pectin, pentose, metabolic engineering, Saccharomyces cerevisiae
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